Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment

Cancer-Derived VEGF-C Increases Chemokine Production in Lymphatic Endothelial Cells to Promote CXCR2-Dependent Cancer Invasion and MDSC Recruitment

Breast cancer-derived vascular endothelial growth factor-C (VEGF-C) has been shown to enhance lymphangiogenesis in lymph nodes to accelerate cancer metastasis. However, the remodeling of lymph node microenvironments by VEGF-C remains elusive. By in vivo selection, we established a subline (named as...

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Bibliographic Details
Main Authors: Jing-Yi Chen, You-Syuan Lai, Pei-Yi Chu, Shih-Hsuan Chan, Lu-Hai Wang, Wen-Chun Hung
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
vascular endothelial growth factor-C
CXC chemokine receptor 2
lymphovascular niche
myeloid-derived suppressor cells
Online Access:https://www.mdpi.com/2072-6694/11/8/1120

Internet

https://www.mdpi.com/2072-6694/11/8/1120

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