Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis

Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis

PDGF-BB/PDGFR-ββ signaling plays very crucial roles in the process of many diseases such as liver fibrosis. However, drug candidates with selective affinities for PDGF-B/PDGFR-β remain deficient. Here, we identified a natural cyclopeptide termed destruxin A5 that effectively inhibits PDGF-BB-induced...

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Bibliographic Details
Main Authors: Xingqi Wang, Xuefeng Wu, Aihua Zhang, Shiyu Wang, Chunhui Hu, Wei Chen, Yan Shen, Renxiang Tan, Yang Sun, Qiang Xu
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:EBioMedicine
Subjects:
Destruxin A5
PDGF-B/PDGFR-β
Protein–protein interface
Selective inhibitor
Liver fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416301311

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http://www.sciencedirect.com/science/article/pii/S2352396416301311

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