Different promoter affinities account for specificity in MYC-dependent gene regulation

Different promoter affinities account for specificity in MYC-dependent gene regulation

Enhanced expression of the MYC transcription factor is observed in the majority of tumors. Two seemingly conflicting models have been proposed for its function: one proposes that MYC enhances expression of all genes, while the other model suggests gene-specific regulation. Here, we have explored the...

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Bibliographic Details
Main Authors: Francesca Lorenzin, Uwe Benary, Apoorva Baluapuri, Susanne Walz, Lisa Anna Jung, Björn von Eyss, Caroline Kisker, Jana Wolf, Martin Eilers, Elmar Wolf
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
MYC
promoter affinity
ChIP-sequencing
mathematical modeling
WDR5
MIZ1
Online Access:https://elifesciences.org/articles/15161

Internet

https://elifesciences.org/articles/15161

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