Effects of Nicotine on the Neurophysiological and Behavioral Effects of Ketamine in Humans

Effects of Nicotine on the Neurophysiological and Behavioral Effects of Ketamine in Humans

Background: N-methyl-D-aspartate (NMDA) receptor hypofunction has been implicated in the pathophysiology of schizophrenia and its associated neurocognitive impairments. The high rate of cigarette smoking in schizophrenia raises questions about how nicotine modulates putative NMDA receptor hypofunct...

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Bibliographic Details
Main Authors: Daniel H Mathalon, Kyung-Heup eAhn, Edward ePerry, Hyun-Sang eCho, Brian J Roach, Rebecca eBlais, Savita eBhakta, Mohini eRanganathan, Judith M Ford, Deepak C D'Souza
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Psychiatry
Subjects:
Ketamine
Nicotine
Schizophrenia
mismatch negativity
P3a
event-related potential (ERP)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00003/full

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http://journal.frontiersin.org/Journal/10.3389/fpsyt.2014.00003/full

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