RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy.
Cervical cancer is one of the most common cancers in women worldwide, being high-risk group the HPV infected, the leading etiological factor. The raf kinase inhibitory protein (RKIP) has been associated with tumor progression and metastasis in several human neoplasms, however its role on cervical ca...
Main Authors: | Olga Martinho, Filipe Pinto, Sara Granja, Vera Miranda-Gonçalves, Marise A R Moreira, Luis F J Ribeiro, Celso di Loreto, Marsha R Rosner, Adhemar Longatto-Filho, Rui Manuel Reis |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2013-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3602518?pdf=render |
Similar Items
-
Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.
by: Olga Martinho, et al.
Published: (2012-01-01) -
RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes
by: Elena Bevilacqua, et al.
Published: (2012-01-01) -
RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer
by: Maria Gabriela-Freitas, et al.
Published: (2019-11-01) -
Current Status of Raf Kinase Inhibitor Protein (RKIP) in Lung Cancer: Behind RTK Signaling
by: Ana Raquel-Cunha, et al.
Published: (2019-05-01) -
Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands.
by: Anne N Shemon, et al.
Published: (2010-05-01)