Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats

Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats

Cytochrome P450 (CYP-450) metabolites of arachidonic acid: epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) have established role in regulation of blood pressure (BP) and kidney function. EETs deficiency and increased renal formation of 20-HETE contribute to hypertensio...

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Bibliographic Details
Main Authors: Agnieszka Walkowska, Luděk Červenka, John D. Imig, John R. Falck, Janusz Sadowski, Elżbieta Kompanowska-Jezierska
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Physiology
Subjects:
hypertension
20-HETE antagonist
EET analog
soluble epoxide hydrolase
epoxyeicosatrienoic acids
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.622882/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.622882/full

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