Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin

Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin

The effect of iron regulatory protein-2 (IRP2) on ferritin expression and neuronal vulnerability to hemoglobin was assessed in primary cortical cell cultures prepared from wild-type and IRP2 knockout mice. Baseline levels of H and L-ferritin subunits were significantly increased in IRP2 knockout neu...

Full description

Bibliographic Details
Main Authors: Raymond F. Regan, Mai Chen, Zhi Li, Xuefeng Zhang, Luna Benvenisti-Zarom, Jing Chen-Roetling
Format: Article
Language:English
Published: Elsevier 2008-08-01
Series:Neurobiology of Disease
Subjects:
Cell culture
Free radical
Iron
Hemoglobin toxicity
Intracerebral hemorrhage
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000879

Internet

http://www.sciencedirect.com/science/article/pii/S0969996108000879

Similar Items