Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit

Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit

Signaling networks are spatiotemporally organized to sense diverse inputs, process information, and carry out specific cellular tasks. In β cells, Ca2+, cyclic adenosine monophosphate (cAMP), and Protein Kinase A (PKA) exist in an oscillatory circuit characterized by a high degree of feedback. Here,...

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Bibliographic Details
Main Authors: Brian Tenner, Michael Getz, Brian Ross, Donya Ohadi, Christopher H Bohrer, Eric Greenwald, Sohum Mehta, Jie Xiao, Padmini Rangamani, Jin Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
signaling compartmentalization
cAMP
pancreatic beta cell
Online Access:https://elifesciences.org/articles/55013

Internet

https://elifesciences.org/articles/55013

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