Single-Dose Immunization With a Chimpanzee Adenovirus-Based Vaccine Induces Sustained and Protective Immunity Against SARS-CoV-2 Infection

Single-Dose Immunization With a Chimpanzee Adenovirus-Based Vaccine Induces Sustained and Protective Immunity Against SARS-CoV-2 Infection

The development of a safe and effective vaccine against SARS-CoV-2, the causative agent of pandemic coronavirus disease-2019 (COVID-19), is a global priority. Here, we aim to develop novel SARS-CoV-2 vaccines based on a derivative of less commonly used rare adenovirus serotype AdC68 vector. Three va...

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Bibliographic Details
Main Authors: Mingxi Li, Jingao Guo, Shuaiyao Lu, Runhong Zhou, Hongyang Shi, Xuanling Shi, Lin Cheng, Qingtai Liang, Hongqi Liu, Pui Wang, Nan Wang, Yifeng Wang, Lili Fu, Man Xing, Ruoke Wang, Bin Ju, Li Liu, Siu-Ying Lau, Wenxu Jia, Xin Tong, Lin Yuan, Yong Guo, Hai Qi, Qi Zhang, Zhen Huang, Honglin Chen, Zheng Zhang, Zhiwei Chen, Xiaozhong Peng, Dongming Zhou, Linqi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2 vaccine
chimpanzee adenovirus vector
spike protein
single-dose immunization
protective immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.697074/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.697074/full

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