Thematic review series: Lipid Posttranslational Modifications. Fighting parasitic disease by blocking protein farnesylation

Thematic review series: Lipid Posttranslational Modifications. Fighting parasitic disease by blocking protein farnesylation

Protein farnesylation is a form of posttranslational modification that occurs in most, if not all, eukaryotic cells. Inhibitors of protein farnesyltransferase (PFTIs) have been developed as anticancer chemotherapeutic agents. Using the knowledge gained from the development of PFTIs for the treatment...

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Bibliographic Details
Main Authors: Richard T. Eastman, Frederick S. Buckner, Kohei Yokoyama, Michael H. Gelb, Wesley C. Van Voorhis
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Journal of Lipid Research
Subjects:
antiprotozoal drugs
Plasmodium
Trypanosoma
Toxoplasma
Giardia
Entamoeba
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520336257

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http://www.sciencedirect.com/science/article/pii/S0022227520336257

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