Cullin3-TNFAIP1 E3 Ligase Controls Inflammatory Response in Hepatocellular Carcinoma Cells via Ubiquitination of RhoB

Cullin3-TNFAIP1 E3 Ligase Controls Inflammatory Response in Hepatocellular Carcinoma Cells via Ubiquitination of RhoB

Rho family GTPase RhoB is the critical signaling component controlling the inflammatory response elicited by pro-inflammatory cytokines. However, the underlying mechanisms of RhoB degradation in inflammatory response remain unclear. In this study, for the first time, we identified that TNFAIP1, an a...

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Bibliographic Details
Main Authors: Yue Liu, Wenjuan Zhang, Shiwen Wang, Lili Cai, Yanyu Jiang, Yongfu Pan, Yupei Liang, Jingrong Xian, Lijun Jia, Lihui Li, Hu Zhao, Yanmei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
RhoB
CRL3s
TNFAIP1
inflammatory response
MAPK signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.617134/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.617134/full

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