Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca2+-permeable Cationic Channel in lung carcinoma cells

Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca2+-permeable Cationic Channel in lung carcinoma cells

Abstract Background Phospholipid phosphatase 4 (PPAPDC1A or PLPP4) has been demonstrated to be involved in the malignant process of many cancers. The purpose of this study was to investigate the clinical significance and biological roles of PLPP4 in lung carcinoma. Methods PLPP4 expression was exami...

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Bibliographic Details
Main Authors: Xin Zhang, Lan Zhang, Bihua Lin, Xingxing Chai, Ronggang Li, Yuehua Liao, Xinghui Deng, Qiongru Liu, Wenli Yang, Yubo Cai, Wei Zhou, Zhichao Lin, Wenhai Huang, Meigong Zhong, Fangyong Lei, Jinhua Wu, Shuaishuai Yu, Xiaoping Li, Shangren Li, Yueyue Li, Jincheng Zeng, Wansheng Long, Dong Ren, Yanming Huang
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Molecular Cancer
Subjects:
PLPP4
Proliferation
Cell cycle
Tumorigenesis
Ca2+-permeable cationic channel
Therapeutic target
Online Access:http://link.springer.com/article/10.1186/s12943-017-0717-5

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http://link.springer.com/article/10.1186/s12943-017-0717-5

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