Retinoic acid activates two pathways required for meiosis in mice.
In all sexually reproducing organisms, cells of the germ line must transition from mitosis to meiosis. In mice, retinoic acid (RA), the extrinsic signal for meiotic initiation, activates transcription of Stra8, which is required for meiotic DNA replication and the subsequent processes of meiotic pro...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-08-01
|
Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC4125102?pdf=render |
id |
doaj-08f3a1f3bfa04e63878513edce665a0c |
---|---|
record_format |
Article |
spelling |
doaj-08f3a1f3bfa04e63878513edce665a0c2020-11-24T21:36:54ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042014-08-01108e100454110.1371/journal.pgen.1004541Retinoic acid activates two pathways required for meiosis in mice.Jana KoubovaYueh-Chiang HuTanmoy BhattacharyyaY Q Shirleen SohMark E GillMary L GoodheartCathryn A HogarthMichael D GriswoldDavid C PageIn all sexually reproducing organisms, cells of the germ line must transition from mitosis to meiosis. In mice, retinoic acid (RA), the extrinsic signal for meiotic initiation, activates transcription of Stra8, which is required for meiotic DNA replication and the subsequent processes of meiotic prophase. Here we report that RA also activates transcription of Rec8, which encodes a component of the cohesin complex that accumulates during meiotic S phase, and which is essential for chromosome synapsis and segregation. This RA induction of Rec8 occurs in parallel with the induction of Stra8, and independently of Stra8 function, and it is conserved between the sexes. Further, RA induction of Rec8, like that of Stra8, requires the germ-cell-intrinsic competence factor Dazl. Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function.http://europepmc.org/articles/PMC4125102?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jana Koubova Yueh-Chiang Hu Tanmoy Bhattacharyya Y Q Shirleen Soh Mark E Gill Mary L Goodheart Cathryn A Hogarth Michael D Griswold David C Page |
spellingShingle |
Jana Koubova Yueh-Chiang Hu Tanmoy Bhattacharyya Y Q Shirleen Soh Mark E Gill Mary L Goodheart Cathryn A Hogarth Michael D Griswold David C Page Retinoic acid activates two pathways required for meiosis in mice. PLoS Genetics |
author_facet |
Jana Koubova Yueh-Chiang Hu Tanmoy Bhattacharyya Y Q Shirleen Soh Mark E Gill Mary L Goodheart Cathryn A Hogarth Michael D Griswold David C Page |
author_sort |
Jana Koubova |
title |
Retinoic acid activates two pathways required for meiosis in mice. |
title_short |
Retinoic acid activates two pathways required for meiosis in mice. |
title_full |
Retinoic acid activates two pathways required for meiosis in mice. |
title_fullStr |
Retinoic acid activates two pathways required for meiosis in mice. |
title_full_unstemmed |
Retinoic acid activates two pathways required for meiosis in mice. |
title_sort |
retinoic acid activates two pathways required for meiosis in mice. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Genetics |
issn |
1553-7390 1553-7404 |
publishDate |
2014-08-01 |
description |
In all sexually reproducing organisms, cells of the germ line must transition from mitosis to meiosis. In mice, retinoic acid (RA), the extrinsic signal for meiotic initiation, activates transcription of Stra8, which is required for meiotic DNA replication and the subsequent processes of meiotic prophase. Here we report that RA also activates transcription of Rec8, which encodes a component of the cohesin complex that accumulates during meiotic S phase, and which is essential for chromosome synapsis and segregation. This RA induction of Rec8 occurs in parallel with the induction of Stra8, and independently of Stra8 function, and it is conserved between the sexes. Further, RA induction of Rec8, like that of Stra8, requires the germ-cell-intrinsic competence factor Dazl. Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function. |
url |
http://europepmc.org/articles/PMC4125102?pdf=render |
work_keys_str_mv |
AT janakoubova retinoicacidactivatestwopathwaysrequiredformeiosisinmice AT yuehchianghu retinoicacidactivatestwopathwaysrequiredformeiosisinmice AT tanmoybhattacharyya retinoicacidactivatestwopathwaysrequiredformeiosisinmice AT yqshirleensoh retinoicacidactivatestwopathwaysrequiredformeiosisinmice AT markegill retinoicacidactivatestwopathwaysrequiredformeiosisinmice AT marylgoodheart retinoicacidactivatestwopathwaysrequiredformeiosisinmice AT cathrynahogarth retinoicacidactivatestwopathwaysrequiredformeiosisinmice AT michaeldgriswold retinoicacidactivatestwopathwaysrequiredformeiosisinmice AT davidcpage retinoicacidactivatestwopathwaysrequiredformeiosisinmice |
_version_ |
1725939478238855168 |