The combination of nano-calcium sulfate/platelet rich plasma gel scaffold with BMP2 gene-modified mesenchymal stem cells promotes bone regeneration in rat critical-sized calvarial defects

The combination of nano-calcium sulfate/platelet rich plasma gel scaffold with BMP2 gene-modified mesenchymal stem cells promotes bone regeneration in rat critical-sized calvarial defects

Abstract Background Mesenchymal stem cells (MSCs) can be differentiated into an osteoblastic lineage in the presence of growth factors (GFs). Platelet-rich plasma (PRP), which can be easily isolated from whole blood, contains a large amount of GFs, and, therefore, promotes bone growth and regenerati...

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Bibliographic Details
Main Authors: Zunpeng Liu, Xue Yuan, Gabriela Fernandes, Rosemary Dziak, Ciprian N. Ionita, Chunyi Li, Changdong Wang, Shuying Yang
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Stem Cell Research & Therapy
Subjects:
Bone morphogenetic protein 2
Mesenchymal stem cells
Platelet-rich plasma
Critical-sized bone defect
Bone tissue engineering
Bone scaffolds
Online Access:http://link.springer.com/article/10.1186/s13287-017-0574-6

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http://link.springer.com/article/10.1186/s13287-017-0574-6

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