Deep sequencing of human papillomavirus positive loco-regionally advanced oropharyngeal squamous cell carcinomas reveals novel mutational signature

Deep sequencing of human papillomavirus positive loco-regionally advanced oropharyngeal squamous cell carcinomas reveals novel mutational signature

Abstract Background The genetic profile for human papilloma virus positive (HPV+) oropharyngeal squamous cell carcinomas (OPSCC) remains largely unknown. The purpose of this study was to sequence tissue material from a large cohort of locoregionally-advanced HPV+ OPSCCs. Methods We performed targete...

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Bibliographic Details
Main Authors: Christian Grønhøj, David H. Jensen, Tina Agander, Katalin Kiss, Estrid Høgdall, Lena Specht, Frederik Otzen Bagger, Finn Cilius Nielsen, Christian von Buchwald
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Cancer
Subjects:
Gene sequencing
Deep sequencing
HPV
Human papilloma virus
Oropharyngeal cancer
Online Access:http://link.springer.com/article/10.1186/s12885-018-4567-3

Internet

http://link.springer.com/article/10.1186/s12885-018-4567-3

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