Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior

Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior

Osteosarcoma (OS) is a heterogeneous and rare disease with a disproportionate impact because it mainly affects children and adolescents. Lamentably, more than half of patients with OS succumb to metastatic disease. Clarification of the etiology of the disease, development of better strategies to man...

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Bibliographic Details
Main Authors: Milcah C. Scott, Hirotaka Tomiyasu, John R. Garbe, Ingrid Cornax, Clarissa Amaya, M. Gerard O'Sullivan, Subbaya Subramanian, Brad A. Bryan, Jaime F. Modiano
Format: Article
Language:English
Published: The Company of Biologists 2016-12-01
Series:Disease Models & Mechanisms
Subjects:
Osteosarcoma
Metastasis
Heterotypic models
Xenograft
Comparative studies
Tumor–stromal interactions
Online Access:http://dmm.biologists.org/content/9/12/1435

Internet

http://dmm.biologists.org/content/9/12/1435

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