An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia

An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia

Dozens of Gram negative pathogens use one or more type III secretion systems (T3SS) to disarm host defenses or occupy a beneficial niche during infection of a host organism. While the T3SS represents an attractive drug target and dozens of compounds with T3SS inhibitory activity have been identified...

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Bibliographic Details
Main Authors: Jessica M. Morgan, Hanh N. Lam, Jocelyn Delgado, Justin Luu, Sina Mohammadi, Ralph R. Isberg, Helen Wang, Victoria Auerbuch
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
type III secretion system
T3SS
T3SS inhibitor
Yersinia
pYV
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00404/full

Internet

https://www.frontiersin.org/article/10.3389/fcimb.2018.00404/full

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