Increasing evidence of mechanical force as a functional regulator in smooth muscle myosin light chain kinase

Increasing evidence of mechanical force as a functional regulator in smooth muscle myosin light chain kinase

Mechanosensitive proteins are key players in cytoskeletal remodeling, muscle contraction, cell migration and differentiation processes. Smooth muscle myosin light chain kinase (smMLCK) is a member of a diverse group of serine/threonine kinases that feature cytoskeletal association. Its catalytic act...

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Bibliographic Details
Main Authors: Fabian Baumann, Magnus Sebastian Bauer, Martin Rees, Alexander Alexandrovich, Mathias Gautel, Diana Angela Pippig, Hermann Eduard Gaub
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
smooth muscle myosin light chain kinase
force-activation
cytoskeleton
auto-inhibition
single-molecule force spectroscopy
atomic force microscopy
Online Access:https://elifesciences.org/articles/26473

Internet

https://elifesciences.org/articles/26473

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