Unilateral Carotid Body Resection in Resistant Hypertension

Unilateral Carotid Body Resection in Resistant Hypertension

Animal and human data indicate pathological afferent signaling emanating from the carotid body that drives sympathetically mediated elevations in blood pressure in conditions of hypertension. This first-in-man, proof-of-principle study tested the safety and feasibility of unilateral carotid body res...

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Bibliographic Details
Main Authors: Krzysztof Narkiewicz, MD, Laura E.K. Ratcliffe, BSc, MBBS, Emma C. Hart, PhD, Linford J.B. Briant, PhD, Marzena Chrostowska, PhD, Jacek Wolf, MD, Anna Szyndler, MD, Dagmara Hering, MD, Ana P. Abdala, PhD, Nathan Manghat, MD, Amy E. Burchell, MA, BMBCh, Claire Durant, PhD, Melvin D. Lobo, Paul A. Sobotka, MD, Nikunj K. Patel, MBBS, MD, James C. Leiter, MD, Zoar J. Engelman, PhD, Angus K. Nightingale, MB, BChir, MD, Julian F.R. Paton, PhD
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:JACC: Basic to Translational Science
Subjects:
afferent drive
baroreceptor reflex
hypertension
hypoxia
peripheral chemoreceptor
sympathetic nervous system
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X1630064X

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http://www.sciencedirect.com/science/article/pii/S2452302X1630064X

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