A maximum likelihood algorithm for reconstructing 3D structures of human chromosomes from chromosomal contact data

A maximum likelihood algorithm for reconstructing 3D structures of human chromosomes from chromosomal contact data

Abstract Background The development of chromosomal conformation capture techniques, particularly, the Hi-C technique, has made the analysis and study of the spatial conformation of a genome an important topic in bioinformatics and computational biology. Aided by high-throughput next generation seque...

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Bibliographic Details
Main Authors: Oluwatosin Oluwadare, Yuxiang Zhang, Jianlin Cheng
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Genomics
Subjects:
Hi-C
3D chromosome structure
Gradient ascent
Chromosome conformation capture
3D genome
Online Access:http://link.springer.com/article/10.1186/s12864-018-4546-8

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http://link.springer.com/article/10.1186/s12864-018-4546-8

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