Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes

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Summary: Differentiation of intestinal T helper 17 (Th17) cells, which contribute to mucosal barrier protection from invasive pathogens, is dependent on colonization with distinct commensal bacteria. Segmented filamentous bacteria (SFB) are sufficient to support Th17 cell differentiation in mouse, b...

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Bibliographic Details
Main Authors: Teruyuki Sano, Takahiro Kageyama, Victoria Fang, Ranit Kedmi, Carlos Serafin Martinez, Jhimmy Talbot, Alessandra Chen, Ivan Cabrera, Oleksandra Gorshko, Reina Kurakake, Yi Yang, Charles Ng, Susan R. Schwab, Dan R. Littman
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
mucosal immunology
ileum
T cell activation
nuclear receptors
lymphocyte homing
cytokine receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721010469

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http://www.sciencedirect.com/science/article/pii/S2211124721010469

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