The molecular basis of thin filament activation: from single molecule to muscle

Abstract For muscles to effectively power locomotion, trillions of myosin molecules must rapidly attach and detach from the actin thin filament. This is accomplished by precise regulation of the availability of the myosin binding sites on actin (i.e. activation). Both calcium (Ca++) and myosin bindi...

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Bibliographic Details
Main Authors: Thomas Longyear, Sam Walcott, Edward P. Debold
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01604-8