UVB-mediated down-regulation of proteasome in cultured human primary pterygium fibroblasts

UVB-mediated down-regulation of proteasome in cultured human primary pterygium fibroblasts

Abstract Background Pterygium is a condition characterized by epithelial overgrowth of the cornea, inflammatory cell infiltration and an abnormal extracellular matrix accumulation. Chronic UV exposure is considered as a pathogenic factor of this disease. Proteasome is an intracellular multi-subunit...

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Bibliographic Details
Main Authors: Alexios J. Aletras, Ioannis Trilivas, Maria-Elpida Christopoulou, Sotiria Drakouli, Constantine D. Georgakopoulos, Nikolaos Pharmakakis
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Ophthalmology
Subjects:
Pterygium
Fibroblasts
Proteasome
UVB irradiation
Nrf2-ARE pathway
Src kinases
Online Access:http://link.springer.com/article/10.1186/s12886-018-0987-8

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http://link.springer.com/article/10.1186/s12886-018-0987-8

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