Asymmetric Recruitment of β-Arrestin1/2 by the Angiotensin II Type I and Prostaglandin F2α Receptor Dimer

Asymmetric Recruitment of β-Arrestin1/2 by the Angiotensin II Type I and Prostaglandin F2α Receptor Dimer

Initially identified as monomers, G protein-coupled receptors (GPCRs) can also form functional homo- and heterodimers that act as distinct signaling hubs for cellular signal integration. We previously found that the angiotensin II (Ang II) type 1 receptor (AT1R) and the prostaglandin F2α (PGF2α) rec...

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Bibliographic Details
Main Authors: Dany Fillion, Dominic Devost, Rory Sleno, Asuka Inoue, Terence E. Hébert
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Endocrinology
Subjects:
G protein-coupled receptor (GPCR)
dimerization
allosteric regulation
arrestin
angiotensin
prostaglandin
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00162/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00162/full

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