Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): virtual screening and activity assays.

BACKGROUND: There has been great interest in determining whether natural products show biological activity toward protein targets of pharmacological relevance. One target of particular interest is DPP-IV whose most important substrates are incretins that, among other beneficial effects, stimulates i...

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Main Authors: Laura Guasch, Maria José Ojeda, Noemí González-Abuín, Esther Sala, Adrià Cereto-Massagué, Miquel Mulero, Cristina Valls, Montserrat Pinent, Anna Ardévol, Santiago Garcia-Vallvé, Gerard Pujadas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3440348?pdf=render