Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice

Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice

Several genetic defects of the nucleotide excision repair (NER) pathway, including deficiency of the Excision Repair Cross-Complementing rodent repair deficiency, complementation group 1 (ERCC1), result in pre-mature aging, impaired growth, microcephaly and delayed development of the cerebellum. The...

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Bibliographic Details
Main Authors: Scott C. Smith, Andria R. Robinson, Laura J. Niedernhofer, Michal Hetman
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
Neurodegeneration
DNA repair
DNA damage
Lipid metabolism
RNA microarrays
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111004116

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http://www.sciencedirect.com/science/article/pii/S0969996111004116

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