Inheritable testicular metabolic memory of high-fat diet causes transgenerational sperm defects in mice

Abstract The consumption of energy-dense diets has contributed to an increase in the prevalence of obesity and its comorbidities worldwide. The adoption of unhealthy feeding habits often occurs at early age, prompting the early onset of metabolic disease with unknown consequences for reproductive fu...

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Bibliographic Details
Main Authors: Luís Crisóstomo, Ivana Jarak, Luís P. Rato, João F. Raposo, Rachel L. Batterham, Pedro F. Oliveira, Marco G. Alves
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88981-3