Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets

Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets

The Food and Drug Administration Adverse Event Reporting System (FAERS) remains the primary source for post-marketing pharmacovigilance. The system is largely un-curated, unstandardized, and lacks a method for linking drugs to the chemical structures of their active ingredients, increasing noise and...

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Bibliographic Details
Main Authors: Mateusz Maciejewski, Eugen Lounkine, Steven Whitebread, Pierre Farmer, William DuMouchel, Brian K Shoichet, Laszlo Urban
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
adverse drug reactions
FAERS
big data
data analysis
Online Access:https://elifesciences.org/articles/25818

Internet

https://elifesciences.org/articles/25818

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