SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling.

SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling.

Recessive mutations in the SDCCAG8 gene cause a nephronophthisis-related ciliopathy with Bardet-Biedl syndrome-like features in humans. Our previous characterization of the orthologous Sdccag8gt/gt mouse model recapitulated the retinal-renal disease phenotypes and identified impaired DNA damage resp...

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Bibliographic Details
Main Authors: Rannar Airik, Markus Schueler, Merlin Airik, Jang Cho, Kelsey A Ulanowicz, Jonathan D Porath, Toby W Hurd, Simon Bekker-Jensen, Jacob M Schrøder, Jens S Andersen, Friedhelm Hildebrandt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4880186?pdf=render

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http://europepmc.org/articles/PMC4880186?pdf=render

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