Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes

Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes

Abstract Cancer‐associated fibroblasts are essential modifiers of the tumor microenvironment. The collagen‐binding integrin α11β1 has been proposed to be upregulated in a pro‐tumorigenic subtype of cancer‐associated fibroblasts. Here, we analyzed the expression and clinical relevance of integrin α11...

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Bibliographic Details
Main Authors: Hilde Ytre‐Hauge Smeland, Cecilie Askeland, Elisabeth Wik, Gøril Knutsvik, Anders Molven, Reidunn J Edelmann, Rolf K Reed, David J Warren, Donald Gullberg, Linda Stuhr, Lars A Akslen
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:The Journal of Pathology: Clinical Research
Subjects:
integrin α11β1
monoclonal antibody
breast cancer
cancer associated fibroblasts
myoepithelial cells
clinico‐pathologic features
Online Access:https://doi.org/10.1002/cjp2.148

Internet

https://doi.org/10.1002/cjp2.148

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