Transcriptional heterogeneity between primary adult grey and white matter astrocytes underlie differences in modulation of in vitro myelination

Transcriptional heterogeneity between primary adult grey and white matter astrocytes underlie differences in modulation of in vitro myelination

Abstract Background Multiple sclerosis (MS) is an inflammation-mediated demyelinating disease of the central nervous system that eventually results in secondary axonal degeneration due to remyelination failure. Successful remyelination is orchestrated by astrocytes (ASTRs) and requires sequential ac...

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Bibliographic Details
Main Authors: Inge L. Werkman, Marissa L. Dubbelaar, Pieter van der Vlies, Jelkje J. de Boer-Bergsma, Bart J. L. Eggen, Wia Baron
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Neuroinflammation
Subjects:
Astrocytes
Multiple sclerosis
Myelination
Oligodendrocyte
Region
Online Access:https://doi.org/10.1186/s12974-020-02045-3

Internet

https://doi.org/10.1186/s12974-020-02045-3

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