Bone marrow mesenchymal stem cell-derived exosomes promote plasminogen activator inhibitor 1 expression in vascular cells in the local microenvironment during rabbit osteonecrosis of the femoral head

Bone marrow mesenchymal stem cell-derived exosomes promote plasminogen activator inhibitor 1 expression in vascular cells in the local microenvironment during rabbit osteonecrosis of the femoral head

Abstract Background Nontraumatic osteonecrosis of the femoral head (NONFH) is a highly disabling orthopedic disease in young individuals. Plasminogen activator inhibitor 1 (PAI-1) has been reported to be positively associated with NONFH. We aimed to investigate the dysregulating PAI-1 in bone marrow...

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Bibliographic Details
Main Authors: Lu Li, Yikai Wang, Xiaobing Yu, Yongming Bao, Lijia An, Xiaowei Wei, Weiting Yu, Baoyi Liu, Junlei Li, Jiahui Yang, Yan Xia, Ge Liu, Fang Cao, Xiuzhi Zhang, Dewei Zhao
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Stem Cell Research & Therapy
Subjects:
Nontraumatic osteonecrosis of the femoral head
PAI-1
Bone marrow mesenchymal stem cells
Exosome
miRNA
Online Access:http://link.springer.com/article/10.1186/s13287-020-01991-2

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http://link.springer.com/article/10.1186/s13287-020-01991-2

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