Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study

Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study

<p>Abstract</p> <p>Background</p> <p>The development of cancer has been associated with epigenetic alterations such as aberrant histone deacetylase (HDAC) activity. It was recently reported that valproic acid is an effective inhibitor of histone deacetylases and as such...

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Bibliographic Details
Main Authors: Cabrera Gustavo, Perez-Plasencia Carlos, Zambrano Pilar, Garcia-Lopez Patricia, Gonzalez-Fierro Aurora, Cantu David, Candelaria Myrna, Cetina Lucely, Taja-Chayeb Lucia, Perez-Cardenas Enrique, Segura-Pacheco Blanca, Chavez-Blanco Alma, Trejo-Becerril Catalina, Angeles Enrique, Duenas-Gonzalez Alfonso
Format: Article
Language:English
Published: BMC 2005-07-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/4/1/22

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http://www.molecular-cancer.com/content/4/1/22

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