Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel

Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel

P2X2 receptors (P2X2R) exhibit a slow desensitization during the initial ATP application and a progressive, calcium-dependent increase in rates of desensitization during repetitive stimulation. This pattern is observed in whole-cell recordings from cells expressing recombinant and native P2X2R. Howe...

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Bibliographic Details
Main Authors: Milos B. Rokic, Patricio Castro, Elias Leiva-Salcedo, Melanija Tomic, Stanko S. Stojilkovic, Claudio Coddou
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
purinergic receptor channels
desensitization
ATP
calcium
allosteric
covalent
Online Access:http://www.mdpi.com/1422-0067/19/4/1161

Internet

http://www.mdpi.com/1422-0067/19/4/1161

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