Opposing Roles of Calcium and Intracellular ATP on Gating of the Purinergic P2X2 Receptor Channel
P2X2 receptors (P2X2R) exhibit a slow desensitization during the initial ATP application and a progressive, calcium-dependent increase in rates of desensitization during repetitive stimulation. This pattern is observed in whole-cell recordings from cells expressing recombinant and native P2X2R. Howe...
Main Authors: | Milos B. Rokic, Patricio Castro, Elias Leiva-Salcedo, Melanija Tomic, Stanko S. Stojilkovic, Claudio Coddou |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-04-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/19/4/1161 |
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