Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 Regulates fkbp5 and Metabolism

Glucocorticoid-Responsive Transcription Factor Krüppel-Like Factor 9 Regulates fkbp5 and Metabolism

Krüppel-like factor 9 (Klf9) is a feedforward regulator of glucocorticoid receptor (GR) signaling. Here we show that in zebrafish klf9 is expressed with GR-dependent oscillatory dynamics in synchrony with fkbp5, a GR target that encodes a negative feedback regulator of GR signaling. We found that fk...

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Bibliographic Details
Main Authors: Ian M. Gans, Janelle Grendler, Remy Babich, Nishad Jayasundara, James A. Coffman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
glucocorticoid receptor
Krüppel-like factor 9
fkbp5
cortisol
metabolism
zebrafish
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.727037/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.727037/full

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