Synthesis of (R)-Dihydropyridones as Key Intermediates for an Efficient Access to Piperidine Alkaloids

Synthesis of (R)-Dihydropyridones as Key Intermediates for an Efficient Access to Piperidine Alkaloids

The efficient transformation of D-glucal to (2R)-hydroxymethyldihydro-pyridinone 5 in seven steps and 35 % overall yield is reported. Dihydropyridone 5 constitutes a versatile chiral building block for the synthesis of various piperidine alkaloids. In this regard, 5 was converted to piperidinol 13 a...

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Bibliographic Details
Main Authors: Serkos A Haroutounian, Prokopios Magiatis, Konstantinos M Kasiotis, Evangelia N Tzanetou
Format: Article
Language:English
Published: MDPI AG 2007-04-01
Series:Molecules
Subjects:
Dihydropyridones
piperidine alkaloids
azasugars
asymmetric synthesis
Online Access:http://www.mdpi.com/1420-3049/12/4/735/

Internet

http://www.mdpi.com/1420-3049/12/4/735/

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