Poly(POG)n loaded with recombinant human bone morphogenetic protein-2 accelerates new bone formation in a critical-sized bone defect mouse model

Poly(POG)n loaded with recombinant human bone morphogenetic protein-2 accelerates new bone formation in a critical-sized bone defect mouse model

Abstract Background Delivery of bone morphogenetic protein-2 (BMP-2) via animal-derived absorbable collagen materials is used for the treatment of large bone defects. However, the administration of bovine proteins to humans is associated with the risk of zoonotic complications. We therefore examined...

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Bibliographic Details
Main Authors: Ryo Tazawa, Kentaro Uchida, Hiroaki Minehara, Terumasa Matsuura, Tadashi Kawamura, Hiroyuki Sekiguchi, Kyoko Muneshige, Sho Inoue, Gen Inoue, Masashi Takaso
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Collagen-like peptides
Poly(POG)n
Bone defect
New bone formation
Bone morphogenetic protein-2
Online Access:http://link.springer.com/article/10.1186/s13018-020-01977-z

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http://link.springer.com/article/10.1186/s13018-020-01977-z

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