Poly(POG)n loaded with recombinant human bone morphogenetic protein-2 accelerates new bone formation in a critical-sized bone defect mouse model
Abstract Background Delivery of bone morphogenetic protein-2 (BMP-2) via animal-derived absorbable collagen materials is used for the treatment of large bone defects. However, the administration of bovine proteins to humans is associated with the risk of zoonotic complications. We therefore examined...
Main Authors: | Ryo Tazawa, Kentaro Uchida, Hiroaki Minehara, Terumasa Matsuura, Tadashi Kawamura, Hiroyuki Sekiguchi, Kyoko Muneshige, Sho Inoue, Gen Inoue, Masashi Takaso |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-10-01
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Series: | Journal of Orthopaedic Surgery and Research |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13018-020-01977-z |
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