Association Analysis of NLRP3 Inflammation-Related Gene Promotor Methylation as Well as Mediating Effects on T2DM and Vascular Complications in a Southern Han Chinese Population

Association Analysis of NLRP3 Inflammation-Related Gene Promotor Methylation as Well as Mediating Effects on T2DM and Vascular Complications in a Southern Han Chinese Population

Objective: To explore the association between the methylation levels in the promoter regions of the NLRP3, AIM2, and ASC genes and T2DM and its vascular complications in a Southern Han Chinese population and further analyze their interaction and mediating effects with environmental factors in T2DM.M...

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Bibliographic Details
Main Authors: Zixing Zhou, Lijun Wang, Zihao Wen, Shaoling Zheng, Xiaohong Ye, Dandan Liu, Jing Wu, Xiaoqian Zou, Yumei Liu, Yao Wang, Shirui Dong, Xiuxia Huang, Xiuben Du, Kehui Zhu, Xiaojing Chen, Shiqi Huang, Chengli Zeng, Yajing Han, Baohuan Zhang, Lihong Nie, Guang Yang, Chunxia Jing
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Endocrinology
Subjects:
T2DM
vascular complication
NLRP3
AIM2
ASC
promoter methylation
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00709/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00709/full

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