Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
Glioma therapy with checkpoint inhibitors has limited blood–brain barrier (BBB) penetration and therapeutic effects. Here, the authors develop nanopolymer-conjugated checkpoint inhibitors and show their trans-BBB delivery and anti-glioma efficacy.
Main Authors: | , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-08-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11719-3 |