Mechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib

Mechanisms Underlying the Anti-inflammatory and Immunosuppressive Activity of Ruxolitinib

The JAK-STAT signaling pathway plays a central role in signal transduction in hematopoietic cells, as well as in cells of the immune system. The occurrence in most patients affected by myeloproliferative neoplasms (MPNs) of driver mutations resulting in the constitutive activation of JAK2-dependent...

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Bibliographic Details
Main Authors: Elena Maria Elli, Claudia Baratè, Francesco Mendicino, Francesca Palandri, Giuseppe Alberto Palumbo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
ruxolitinib
JAK inhibitors
immune system
immunosuppression
myeloproliferative neoplasms (MPNs)
natural killer (NK) cells
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01186/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.01186/full

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