A specific proteinase 3 activity footprint in α1-antitrypsin deficiency

A specific proteinase 3 activity footprint in α1-antitrypsin deficiency

α1-Antitrypsin (α1-AT) deficiency is a risk factor for emphysema due to tissue damage by serine proteases. Neutrophil elastase (NE) has long been considered the enzyme responsible. However, proteinase 3 (PR3) also produces the pathological features of chronic obstructive pulmonary disease (COPD), is...

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Bibliographic Details
Main Authors: Paul R. Newby, Diana Crossley, Helena Crisford, James A. Stockley, Richard A. Mumford, Richard I. Carter, Charlotte E. Bolton, Nicholas S. Hopkinson, Ravi Mahadeva, Michael C. Steiner, Tom M.A. Wilkinson, Elizabeth Sapey, Robert A. Stockley
Format: Article
Language:English
Published: European Respiratory Society 2019-08-01
Series:ERJ Open Research
Online Access:http://openres.ersjournals.com/content/5/3/00095-2019.full

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http://openres.ersjournals.com/content/5/3/00095-2019.full

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