In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

Cytostatic effects of doxorubicin in clinically applied doses are often inadequate and limited by systemic toxicity. The main objective of this in vitro study was to determine the anti-tumoral effect (IC<sub>50</sub>) and intracellular accumulation of free and liposomal doxorubicin (DOX)...

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Bibliographic Details
Main Authors: Fredrik Kullenberg, Oliver Degerstedt, Carlemi Calitz, Nataša Pavlović, David Balgoma, Johan Gråsjö, Erik Sjögren, Mikael Hedeland, Femke Heindryckx, Hans Lennernäs
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
hepatocellular carcinoma
doxorubicin
liposome
cell model
intracellular concentration
physiologically based pharmacokinetic model
Online Access:https://www.mdpi.com/2073-4409/10/7/1717

Internet

https://www.mdpi.com/2073-4409/10/7/1717

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