In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma
Cytostatic effects of doxorubicin in clinically applied doses are often inadequate and limited by systemic toxicity. The main objective of this in vitro study was to determine the anti-tumoral effect (IC<sub>50</sub>) and intracellular accumulation of free and liposomal doxorubicin (DOX)...
Main Authors: | Fredrik Kullenberg, Oliver Degerstedt, Carlemi Calitz, Nataša Pavlović, David Balgoma, Johan Gråsjö, Erik Sjögren, Mikael Hedeland, Femke Heindryckx, Hans Lennernäs |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-07-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/10/7/1717 |
Similar Items
-
Mechanistic insights into the intracellular release of doxorubicin from pH-sensitive liposomes
by: Samara Bonesso dos Reis, et al.
Published: (2021-02-01) -
Anthracyclins Increase PUFAs: Potential Implications in ER Stress and Cell Death
by: David Balgoma, et al.
Published: (2021-05-01) -
A comparison between liposomal and nonliposomal formulations of doxorubicin in the treatment of cancer: An updated review
by: Yik Hoe Ngan, et al.
Published: (2016-01-01) -
Morphological changes of doxorubicin-loaded liposomes observed by atomic force microscopy
by: Naoki Takahashi, et al.
Published: (2016-02-01) -
Doxorubicin Loaded Liposomal Nanoparticles Containing Quantum Dot for Treatment of Breast Cancer
by: Javad Shahabi, et al.
Published: (2019-10-01)