Ageing contributes to phenotype transition in a mouse model of periodic paralysis

Ageing contributes to phenotype transition in a mouse model of periodic paralysis

Abstract Background Periodic paralysis (PP) is a rare genetic disorder in which ion channel mutation causes episodic paralysis in association with hyper‐ or hypokalaemia. An unexplained but consistent feature of PP is that a phenotype transition occurs around the age of 40, in which the severity of...

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Bibliographic Details
Main Authors: Karen J. Suetterlin, S. Veronica Tan, Roope Mannikko, Rahul Phadke, Michael Orford, Simon Eaton, Avan A. Sayer, Miranda D. Grounds, Emma Matthews, Linda Greensmith, Michael G. Hanna
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:JCSM Rapid Communications
Subjects:
Ageing; Channelopathy; Periodic paralysis; Sarcopenia; Skeletal muscle; Ion channels
Online Access:https://doi.org/10.1002/rco2.41

Internet

https://doi.org/10.1002/rco2.41

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