A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors

A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors

The G protein-activated Inwardly Rectifying K+-channel (GIRK) modulates heart rate and neuronal excitability. Following G-Protein Coupled Receptor (GPCR)-mediated activation of heterotrimeric G proteins (Gαβγ), opening of the channel is obtained by direct binding of Gβγ subunits. Interestingly, GIRK...

Full description

Bibliographic Details
Main Authors: Shai Berlin, Etay Artzy, Reem Handklo-Jamal, Uri Kahanovitch, Hanna Parnas, Nathan Dascal, Daniel Yakubovich
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
collision-coupling
G-protein cycle
kinetic model
GIRK channel
G-Protein Coupled Receptor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01216/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01216/full

Similar Items