A Collision Coupling Model Governs the Activation of Neuronal GIRK1/2 Channels by Muscarinic-2 Receptors
The G protein-activated Inwardly Rectifying K+-channel (GIRK) modulates heart rate and neuronal excitability. Following G-Protein Coupled Receptor (GPCR)-mediated activation of heterotrimeric G proteins (Gαβγ), opening of the channel is obtained by direct binding of Gβγ subunits. Interestingly, GIRK...
Main Authors: | Shai Berlin, Etay Artzy, Reem Handklo-Jamal, Uri Kahanovitch, Hanna Parnas, Nathan Dascal, Daniel Yakubovich |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-08-01
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Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.01216/full |
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