CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice

CXCR1 and CXCR2 Inhibition by Ladarixin Improves Neutrophil-Dependent Airway Inflammation in Mice

RationaleIncreased IL-8 levels and neutrophil accumulation in the airways are common features found in patients affected by pulmonary diseases such as Asthma, Idiopathic Pulmonary Fibrosis, Influenza-A infection and COPD. Chronic neutrophilic inflammation is usually corticosteroid insensitive and ma...

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Bibliographic Details
Main Authors: Matheus Silverio Mattos, Maximiliano Ruben Ferrero, Lucas Kraemer, Gabriel Augusto Oliveira Lopes, Diego Carlos Reis, Geovanni Dantas Cassali, Fabricio Marcus Silva Oliveira, Laura Brandolini, Marcello Allegretti, Cristiana Couto Garcia, Marco Aurélio Martins, Mauro Martins Teixeira, Remo Castro Russo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
neutrophils (PMNs)
asthma
fibrosis
chronic obstructive pulmonary disease
influenza A (H1N1)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.566953/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.566953/full

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