Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons

Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons

Summary: Loss of the nuclear RNA binding protein TAR DNA binding protein-43 (TDP-43) into cytoplasmic aggregates is the strongest correlate to neurodegeneration in amyotrophic lateral sclerosis and frontotemporal degeneration. The molecular changes associated with the loss of nuclear TDP-43 in human...

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Bibliographic Details
Main Authors: Elaine Y. Liu, Jenny Russ, Christopher P. Cali, Jessica M. Phan, Alexandre Amlie-Wolf, Edward B. Lee
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719304589

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http://www.sciencedirect.com/science/article/pii/S2211124719304589

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